Abstract
Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor alpha (PPARalpha) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzhydryl Compounds / chemical synthesis
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Benzhydryl Compounds / chemistry*
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Benzhydryl Compounds / metabolism*
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DNA-Binding Proteins / agonists*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Humans
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Ligands
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Molecular Structure
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PPAR alpha / agonists*
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PPAR alpha / metabolism*
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Receptors, Cytoplasmic and Nuclear
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Transcription Factors / agonists*
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Transcription Factors / genetics
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Transcription Factors / metabolism*
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Transcription, Genetic / genetics
Substances
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Benzhydryl Compounds
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DNA-Binding Proteins
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Ligands
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PPAR alpha
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Receptors, Cytoplasmic and Nuclear
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Transcription Factors
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farnesoid X-activated receptor
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diphenylmethane